2138299-65-5
Chemical Structure
diABZI-4
- CAS No.: 2138299-65-5
- Formula:C40H50ClN13O6
- Molecular Weight:844.36
InChIKey: MGLGDTLLKBTIKJ-ASTDGNLGSA-N
SMILES: O=C(C1=CC(C)=NN1CC)NC2=NC3=CC(C(N)=O)=CC(OC)=C3N2C/C=C/CN4C5=C(OCCCN(C)C)C=C(C(N)=O)C=C5N=C4NC(C6=CC(C)=NN6CC)=O.Cl
Biological Activity: diABZI-4 is a STING activator and broad-spectrum antiviral agent with immunostimulatory activity. diABZI-4 triggers the TBK1-IRF3 and NF-κB signaling cascades by inducing STING oligomerization, thereby promoting the production of type I/III interferons and various proinflammatory cytokines. diABZI-4 exhibits broad-spectrum antiviral activity and effectively inhibits the replication of influenza A virus, SARS-CoV-2, herpes simplex virus, and other viruses. diABZI-4 also activates lymphocytes and macrophages to provide significant pre- and post-exposure protection in viral disease models. diABZI-4 can be used to study COVID-19, respiratory viral infections, and related immunopathological mechanisms[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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diABZI-4 | 98.33% | diABZI-4 is a STING activator and broad-spectrum antiviral agent with immunostimulatory activity. diABZI-4 triggers the TBK1-IRF3 and NF-κB signaling cascades by inducing STING oligomerization, thereby promoting the production of type I/III interferons and various proinflammatory cytokines. diABZI-4 exhibits broad-spectrum antiviral activity and effectively inhibits the replication of influenza A virus, SARS-CoV-2, herpes simplex virus, and other viruses. diABZI-4 also activates lymphocytes and macrophages to provide significant pre- and post-exposure protection in viral disease models. diABZI-4 can be used to study COVID-19, respiratory viral infections, and related immunopathological mechanisms. | ||||||||||||||||||||
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References
- [1]. Humphries F, et al. A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection. Sci Immunol. 2021;6(59):eabi9002. [Content Brief]
- [2]. Broeckel R, et al. STING agonist induced innate immune responses drive anti-respiratory virus activity in vitro with limited antiviral efficacy in vivo[J]. ACS Infectious Diseases, 2024, 10(9): 3392-3407.
- [3]. Humphries F, et al. Targeting STING oligomerization with small-molecule inhibitors. Proc Natl Acad Sci U S A. 2023;120(33):e2305420120. [Content Brief]
- [4]. Liang W Y. The Potential of STING Modulation as Broad-spectrum Host Antiviral Therapeutics for RNA Viruses[J]. Undergraduate Journal of Experimental Microbiology and Immunology, 2025, 9.
