21739-91-3
21739-91-3
Chemical Structure
Cytembena
- CAS No.: 21739-91-3
- Formula:C11H8BrNaO4
- Molecular Weight:307.07
IUPAC Name: sodium (E)-3-bromo-4-(4-methoxyphenyl)-4-oxobut-2-enoate
InChIKey: DVDCIQWIGOVWEX-MLBSPLJJSA-M
SMILES: O=C(O[Na])/C=C(Br)\C(C1=CC=C(C=C1)OC)=O
Biological Activity: Cytembena is inhibitor for replicative DNA synthesis, purine synthesis and tetrahydrofolate formylase activity. Cytembena ameliorates ovarian or breast cancer, relieves the pain from skeletal metastases[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cytembena | 99.53% | Cytembena is inhibitor for replicative DNA synthesis, purine synthesis and tetrahydrofolate formylase activity. Cytembena ameliorates ovarian or breast cancer, relieves the pain from skeletal metastases. | ||||||||||||||||||||
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References
- [1]. Falkson HC, et al., Phase II trial of cytembena in patients with advanced ovarian and breast cancer. Cancer Treat Rep. 1976 Nov;60(11):1655-8. [Content Brief]
- [2]. Berger NA, et al., Description of a permeable eukaryotic cell system to study agents affecting DNA synthesis: demonstration that cytembena is a direct inhibitor of replicative DNA synthesis. J Natl Cancer Inst. 1977 Apr;58(4):1167-9. [Content Brief]
Keywords
