2201098-03-3
Chemical Structure
HPK1-IN-15
- CAS No.: 2201098-03-3
- Formula:C24H21ClF3N5
- Molecular Weight:471.91
IUPAC Name: 5-(2-chloro-6-(trifluoromethyl)phenyl)-3-(4-(4-methylpiperazin-1-yl)phenyl)-1H-pyrazolo[3,4-c]pyridine
InChIKey: QVGWBTYTEUGLLR-UHFFFAOYSA-N
SMILES: FC(F)(C1=CC=CC(Cl)=C1C2=CC3=C(NN=C3C4=CC=C(N5CCN(CC5)C)C=C4)C=N2)F
Biological Activity: HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50)[1].
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HPK1-IN-15 | HPK1-IN-15 is a potent and selective inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPKl) originally cloned from hematopoietic progenitor cells is a member of MAP kinase kinase kinase kinases (MAP4Ks) family. HPK1-IN-15 is useful in researching, preventing or ameliorating diseases or disorders associated with HPK1 activity such as cancer (extracted from patent WO2018049200A1, compound 50). | |||||||||||||||||||||
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