220119-27-7
Chemical Structure
15-Deoxy-TIC
- CAS No.: 220119-27-7
- Formula:C24H32O3
- Molecular Weight:368.51
InChIKey: UZEWMXSWYKBMJG-ROHPBGETSA-N
SMILES: CC1=CC=CC(CC/C=C/[C@@H]2[C@]3([H])[C@@](C[C@H]2O)([H])C=C(C3)CCCCC(O)=O)=C1
Biological Activity: 15-Deoxy-TIC is a selective central nervous system-type prostacyclin receptor (IP2) ligand that can cross the blood-brain barrier. 15-Deoxy-TIC binds to IP2 with a rat IC50 of 3 nM, activates the cAMP/PKA signaling pathway, and inhibits CXCL9/CXCL10. 15-Deoxy-TIC inhibits oxidative stress/trophic factor withdrawal-induced neuronal apoptosis. 15-Deoxy-TIC can be used for research on focal cerebral ischemia, central nervous system neuronal injury, and neurodegenerative diseases[1][2][3][4][5].
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15-Deoxy-TIC | 15-Deoxy-TIC is a selective central nervous system-type prostacyclin receptor (IP2) ligand that can cross the blood-brain barrier. 15-Deoxy-TIC binds to IP2 with a rat IC50 of 3 nM, activates the cAMP/PKA signaling pathway, and inhibits CXCL9/CXCL10. 15-Deoxy-TIC inhibits oxidative stress/trophic factor withdrawal-induced neuronal apoptosis. 15-Deoxy-TIC can be used for research on focal cerebral ischemia, central nervous system neuronal injury, and neurodegenerative diseases. | |||||||||||||||||||||
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References
- [1]. Takamatsu H, et al. Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia. Brain research. 2002 Jan 25;925(2):176-82. [Content Brief]
- [2]. Wilson SM, et al. Evidence for a second receptor for prostacyclin on human airway epithelial cells that mediates inhibition of CXCL9 and CXCL10 release. Molecular pharmacology. 2011 Mar 1;79(3):586-95. [Content Brief]
- [3]. Suzuki M, et al. 15-Deoxy-16-(m-tolyl)-17, 18, 19, 20-tetranorisocarbacyclin: a simple TIC derivative with potent anti-apoptotic activity for neuronal cells. Chemical Communications. 1999 Jan 1;35(4):307-8.
- [4]. Cui Y, et al. Protective effect of prostaglandin I2 analogs on ischemic delayed neuronal damage in gerbils. Biochemical and biophysical research communications. 1999 Nov 19;265(2):301-4. [Content Brief]
- [5]. Satoh T, et al. CNS-specific prostacyclin ligands as neuronal survival-promoting factors in the brain. The European journal of neuroscience. 1999 Sep;11(9):3115-24. [Content Brief]
