220757-06-2
220757-06-2
Chemical Structure
Apicularen B
- CAS No.: 220757-06-2
- Formula:C33H44N2O11
- Molecular Weight:644.71
InChIKey: JVMDGHNCVYGPGG-ZBGHJEECSA-N
SMILES: O=C(O[C@H]1C/C=C/NC(/C=C\C=C/CC)=O)C(C(C[C@@](O[C@@]2([H])C1)([H])C[C@H](C2)O[C@H](O[C@@H]3CO)[C@@H]([C@H]([C@@H]3O)O)NC(C)=O)=CC=C4)=C4O
Biological Activity: Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Apicularen B | Apicularen B is a V-ATPase inhibitor and cytotoxic macrolide that can be obtained from the myxobacterium Archangium gephyra. Apicularen B can be used in the study of V-ATPase-related diseases, such as osteopetrosis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Köteles I, et al. Synthesis of Potential Haptens with Morphine Skeleton and Determination of Protonation Constants. Molecules. 2020 Sep 2;25(17):4009. [Content Brief]
- [2]. Hong J, et al. Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells. FEBS Lett. 2006 May 15;580(11):2723-30. [Content Brief]
