221564-97-2
221564-97-2
Chemical Structure
K-111
Synonym(s): BM 17.0744
- CAS No.: 221564-97-2
- Formula:C18H25Cl3O2
- Molecular Weight:379.75
IUPAC Name: 2,2-dichloro-12-(4-chlorophenyl)dodecanoic acid
InChIKey: GPCJDSXBRMKASP-UHFFFAOYSA-N
SMILES: O=C(C(Cl)(CCCCCCCCCCC1=CC=C(C=C1)Cl)Cl)O
Biological Activity: K-111 (BM-170744) is an oral active PPAR alpha agonist. K-111 show efficacy in improving insulin resistance, reducing body weight, and ameliorating atherogenic dyslipidemia. K-111 can be used for study of type 2 diabetes, dyslipidaemia, obesity and the metabolic syndrome[1][2].
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K-111 | K-111 (BM-170744) is an oral active PPAR alpha agonist. K-111 show efficacy in improving insulin resistance, reducing body weight, and ameliorating atherogenic dyslipidemia. K-111 can be used for study of type 2 diabetes, dyslipidaemia, obesity and the metabolic syndrome. | |||||||||||||||||||||
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References
- [1]. Schäfer SA, et al. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR)alpha activator, in non-human primates. Biochem Pharmacol. 2004;68(2):239-251. [Content Brief]
- [2]. Ortmeyer HK, et al. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2005;288(6):R1509-R1517. [Content Brief]
