2217671-64-0
2217671-64-0
Chemical Structure
MIR002
- CAS No.: 2217671-64-0
- Formula:C27H29NO5
- Molecular Weight:447.52
InChIKey: YJMADWAPLKRSFA-FPYGCLRLSA-N
SMILES: ONC(COC1=C(C=C(C2=CC=C(C=C2)/C=C/C(O)=O)C=C1)C34CC5CC(CC(C5)C4)C3)=O
Biological Activity: MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo[1].
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MIR002 | 99.0% | MIR002 is a potent and orally active DNA polymerase α (POLA1) and HDAC 11 dual inhibitor. MIR002 induces acetylation of p53, activation of p21, G1/S cell cycle arrest, and apoptosis. MIR002 shows significant antitumor activity in vivo. | ||||||||||||||||||||
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