2244-16-8
2244-16-8
Chemical Structure
(S)-(+)-Carvone
Synonym(s): D-Carvone
- CAS No.: 2244-16-8
- Formula:C10H14O
- Molecular Weight:150.22
IUPAC Name: (S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one
InChIKey: ULDHMXUKGWMISQ-VIFPVBQESA-N
SMILES: C=C([C@H](C1)CC=C(C)C1=O)C
Biological Activity: (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis[1][2][3][4][5][6][7][8][9][10][11][12].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-(+)-Carvone | 99.26% | (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis. | ||||||||||||||||||||
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(S)-(+)-Carvone (Standard) | ≥98% | (S)-(+)-Carvone (Standard) is the analytical standard of (S)-(+)-Carvone. This product is intended for research and analytical applications. (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis. | ||||||||||||||||||||
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References
- [1]. Jan Alexander, et al. Scientific Opinion on the safety assessment of carvone, considering all sources of exposure.European Food Safety Authority (EFSA), Parma, Italy.
- [2]. Lv L, et al. d-Carvone inhibits the JAK/STAT3 signaling pathway and induced the apoptotic cell death in the human gastric cancer AGS cells. J Biochem Mol Toxicol. 2021 May;35(5):e22746. [Content Brief]
- [3]. Wojtunik-Kulesza KA, et al. S-(+)-Carvone, a Monoterpene with Potential Anti-Neurodegenerative Activity-In Vitro, In Vivo and Ex Vivo Studies. Molecules. 2024 Sep 13;29(18):4365. [Content Brief]
- [4]. Iyappan P, et al. D-carvone induced ROS mediated apoptotic cell death in human leukemic cell lines (Molt-4). Bioinformation. 2021 Jan 31;17(1):171-180. [Content Brief]
- [5]. Sousa C, et al. Elucidation of the Mechanism Underlying the Anti-Inflammatory Properties of (S)-(+)-Carvone Identifies a Novel Class of Sirtuin-1 Activators in a Murine Macrophage Cell Line. Biomedicines. 2021 Jul 4;9(7):777. [Content Brief]
- [6]. Huchelmann A, et al. S-carvone suppresses cellulase-induced capsidiol production in Nicotiana tabacum by interfering with protein isoprenylation. Plant Physiol. 2014 Feb;164(2):935-50. [Content Brief]
- [7]. Zhao M, et al. Anti-inflammatory and protective effects of D-carvone on lipopolysaccharide (LPS)-induced acute lung injury in mice. Journal of King Saud University-Science, 2020, 32(2): 1592-1596.
- [8]. Dai M, et al. D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway. Biomed Pharmacother. 2020 Dec;132:110870. [Content Brief]
- [9]. Chen G, et al. Anti-arthritic activity of D-carvone against complete Freund's adjuvant-induced arthritis in rats through modulation of inflammatory cytokines. Korean J Physiol Pharmacol. 2020 Nov 1;24(6):453-462. [Content Brief]
- [10]. Nogoceke FP, et al. Antimanic-like effects of (R)-(-)-carvone and (S)-(+)-carvone in mice. Neurosci Lett. 2016 Apr 21;619:43-8. [Content Brief]
- [11]. Alsanea S, et al. BITC and S-Carvone Restrain High-Fat Diet-Induced Obesity and Ameliorate Hepatic Steatosis and Insulin Resistance. Pharm Res. 2017 Nov;34(11):2241-2249. [Content Brief]
- [12]. Gopalakrishnan T, et al. Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events. Biomed Pharmacother. 2019 Mar;111:178-187. [Content Brief]
