2248552-84-1
2248552-84-1
Chemical Structure
WB436B
- CAS No.: 2248552-84-1
- Formula:C21H20N6O3S
- Molecular Weight:436.49
InChIKey: GSAGESLSAFFQGT-UHFFFAOYSA-N
SMILES: COC1=C(NC(N2CC(SC(NC(C3=CN(C)N=C3)=O)=C4C#N)=C4CC2)=O)C=CC=C1
Biological Activity:
WB436B is a highly selective STAT3 inhibitor. WB436B can selectively inhibit STAT3-Tyr705 phosphorylation and the expression of STAT3 target genes, showing cytotoxic effects on pancreatic cancer cells and inducing apoptosis. WB436B can suppress tumor growth and metastasis in pancreatic cancer mouse models, extending the survival of tumor-bearing mice[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WB436B | 99.93% | WB436B is a highly selective STAT3 inhibitor. WB436B can selectively inhibit STAT3-Tyr705 phosphorylation and the expression of STAT3 target genes, showing cytotoxic effects on pancreatic cancer cells and inducing apoptosis. WB436B can suppress tumor growth and metastasis in pancreatic cancer mouse models, extending the survival of tumor-bearing mice. |
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Structural Analogs
-
Similarity Score 0.84
HY-150603STAT3-IN-13 -
Similarity Score 0.55
HY-138215ADTL-EI1712 -
Similarity Score 0.54
HY-168337SET-171 -
Similarity Score 0.54
HY-1112514SC-207 -
Similarity Score 0.52
HY-180539JT71 -
Similarity Score 0.50
HY-15881TCS JNK 5a -
Similarity Score 0.50
HY-181835AgrC-IN-1 -
Similarity Score 0.47
HY-118914Glucagon receptor antagonist inactive control -
Similarity Score 0.46
HY-18673PROTO-1 -
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