227002-04-2
Chemical Structure
L-764406
- CAS No.: 227002-04-2
- Formula:C15H11ClN2O2S
- Molecular Weight:318.78
IUPAC Name: 2-chloro-3-((phenylsulfonyl)methyl)quinoxaline
InChIKey: AMNQYONRCBZMGT-UHFFFAOYSA-N
SMILES: O=S(CC1=NC2=CC=CC=C2N=C1Cl)(C3=CC=CC=C3)=O
Biological Activity: L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
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L-764406 | L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs. | |||||||||||||||||||||
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