2289736-54-3
2289736-54-3
Chemical Structure
Enpp-1-IN-17
- CAS No.: 2289736-54-3
- Formula:C18H24N4O2
- Molecular Weight:328.41
IUPAC Name: 8-(6,7-dimethoxyquinazolin-4-yl)-2,8-diazaspiro[4.5]decane
InChIKey: JFWDXDVLIPMYII-UHFFFAOYSA-N
SMILES: COC1=CC2=C(N3CCC4(CC3)CNCC4)N=CN=C2C=C1OC
Biological Activity: Enpp-1-IN-17 (example 274) is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. The selectivity ratio for inhibition of cGAMP hydrolysis versus ATP hydrolysis is >6.4[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Enpp-1-IN-17 | 99.65% | Enpp-1-IN-17 (example 274) is a potent ENPP1 inhibitor, with the inhibition constants (Ki values) toward cGAMP and ATP hydrolysis of 100 nM-1 μM and > 1 μM, respectively. The selectivity ratio for inhibition of cGAMP hydrolysis versus ATP hydrolysis is >6.4. | ||||||||||||||||||||
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References
Keywords
