2428738-41-2
2428738-41-2
Chemical Structure
FGFR3-IN-3
- CAS No.: 2428738-41-2
- Formula:C38H49N9O6S
- Molecular Weight:759.92
IUPAC Name: N-(4-((2-(N-ethylsulfamoyl)phenyl)amino)-2-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-5-yl)-3,5-dimethoxybenzamide
InChIKey: UQNRMYUOJMQZHQ-UHFFFAOYSA-N
SMILES: CCNS(=O)(C1=C(C=CC=C1)NC2=NC(NC3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)=NC=C2NC(C6=CC(OC)=CC(OC)=C6)=O)=O
Biological Activity: FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].
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FGFR3-IN-3 | FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer. | |||||||||||||||||||||
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