244277-89-2
244277-89-2
Chemical Structure
J-104129
- CAS No.: 244277-89-2
- Formula:C24H36N2O2
- Molecular Weight:384.55
IUPAC Name: (R)-2-cyclopentyl-2-hydroxy-N-(1-(4-methylpent-3-en-1-yl)piperidin-4-yl)-2-phenylacetamide
InChIKey: YECZUVJTDYORCB-DEOSSOPVSA-N
SMILES: O=C(NC1CCN(CC/C=C(C)/C)CC1)[C@@](O)(C2CCCC2)C3=CC=CC=C3
Biological Activity: J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM). J-104129 is effective in promoting bronchodilation[1][2].
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J-104129 | J-104129 is a selective and orally active muscarinic M3 receptor antagonist (Ki = 4.2 nM). J-104129 is effective in promoting bronchodilation. | |||||||||||||||||||||
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References
- [1]. Mitsuya M, et al. J-104129, a novel muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors. Bioorg Med Chem. 1999 Nov;7(11):2555-67. [Content Brief]
- [2]. Morihiro Mitsuya, et al. Discovery of a muscarinic M3 receptor antagonist with high selectivity for M3 over M2 receptors among 2-[(1S,3S)-3-sulfonylaminocyclopentyl]phenylacetamide derivatives. Bioorg Med Chem. 2000, 8(4): 825-832.
