2489611-06-3
Chemical Structure
ALK5-IN-9
- CAS. Nr.: 2489611-06-3
- Formula:C29H35F3N6O3
- Molecular Weight:572.62
IUPAC Name: 2-(4-(4-((4-((1-cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)oxy)pyridin-2-yl)amino)-2-(trifluoromethyl)phenyl)piperazin-1-yl)ethan-1-ol
InChIKey: QENSSRBZZIISAU-UHFFFAOYSA-N
SMILES: OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1
Biological Activity: ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease[1].
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ALK5-IN-9 | ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease. | |||||||||||||||||||||
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Keywords
