ALK5-IN-9
ALK5-IN-9 (Compound 8h) is a potent and orally active inhibitor of TGFβRI (ALK5). ALK5-IN-9 inhibits ALK5 autophosphorylation and NIH3T3 cell activity with IC50 values of 25 nM and 74.6 nM, respectively. ALK5-IN-9 also shows favorable pharmacokinetic profile and ameliorated hERG inhibition. ALK5-IN-9 has the potential for the research of cancer disease.
For research use only. We do not sell to patients.
- CAS No.: 2489611-06-3
- Formula: C29H35F3N6O3
- Molecular Weight:572.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NIH3T3 | IC50 |
74.6 nM
Compound: 8h
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Antiproliferative activity against mouse NIH/3T3 cells assessed as cell growth inhibition
Antiproliferative activity against mouse NIH/3T3 cells assessed as cell growth inhibition
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[PMID: 35051574] |
Chemical Information
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CAS No. 2489611-06-3
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Molecular Weight 572.62
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Formula C29H35F3N6O3
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SMILES
OCCN1CCN(C2=CC=C(NC3=NC=CC(OC4=CN(C5CC5)N=C4C6CCOCC6)=C3)C=C2C(F)(F)F)CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ALK5-IN-9 Related Classifications
HY-144437 Related Classifications
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