253307-65-2
253307-65-2
Chemical Structure
PBR28
- CAS No.: 253307-65-2
- Formula:C21H20N2O3
- Molecular Weight:348.40
IUPAC Name: N-(2-methoxybenzyl)-N-(4-phenoxypyridin-3-yl)acetamide
InChIKey: DHZBNHMEIOBPAE-UHFFFAOYSA-N
SMILES: O=C(C)N(CC1=C(OC)C=CC=C1)C2=C(OC3=CC=CC=C3)C=CN=C2
Biological Activity: PBR28 is a translocator protein (TSPO) binding positron emission tomography (PET) radiotracer with blood-brain barrier permeability[1][2]. PBR28 binds to TSPO, a marker of microglial activation and neuroinflammation, and is used for neuroinflammation imaging in brain diseases and HIV-infected individuals[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PBR28 | 98.91% | PBR28 is a translocator protein (TSPO) binding positron emission tomography (PET) radiotracer with blood-brain barrier permeability. PBR28 binds to TSPO, a marker of microglial activation and neuroinflammation, and is used for neuroinflammation imaging in brain diseases and HIV-infected individuals. | ||||||||||||||||||||
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References
- [1]. Sander CY, et al. [11C]PBR28 radiotracer kinetics are not driven by alterations in cerebral blood flow. J Cereb Blood Flow Metab. 2021;41(11):3069-3084. [Content Brief]
- [2]. Boerwinkle AH, et al. Comparison of [11C]-PBR28 Binding Between Persons Living With HIV and HIV-Uninfected Individuals. J Acquir Immune Defic Syndr. 2020;85(2):244-251. [Content Brief]
