25518-49-4
Chemical Structure
Isobutyryl-L-carnitine
- CAS No.: 25518-49-4
- Formula:C11H21NO4
- Molecular Weight:231.29
IUPAC Name: (R)-3-(isobutyryloxy)-4-(trimethylammonio)butanoate
InChIKey: LRCNOZRCYBNMEP-SECBINFHSA-N
SMILES: CC(C)C(O[C@H](CC([O-])=O)C[N+](C)(C)C)=O
Biological Activity: Isobutyryl-L-carnitine is a biomarker. Isobutyryl-L-carnitine is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine can be used in research on renal cell carcinoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Isobutyryl-L-carnitine | 99.9% | Isobutyryl-L-carnitine is a biomarker. Isobutyryl-L-carnitine is a product of acyl-CoA dehydrogenases involved in fatty acid β-oxidation, and it buffers the mitochondrial acyl-CoA/CoA ratio, oxidizes branched-chain amino acids, and supports the endogenous antioxidant defense system. Isobutyryl-L-carnitine is a plasma biomarker of hepatic OCT1 transporter inhibition. Isobutyryl-L-carnitine is a urinary biomarker of renal cell carcinoma, and its levels are elevated one year after nephrectomy compared with before nephrectomy. Isobutyryl-L-carnitine can be used in research on renal cell carcinoma. | ||||||||||||||||||||
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References
- [1]. Luo L, et al. A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker. Analytical chemistry. 2020 Jul 21;92(14):9745-9754.
- [2]. Cao C, et al. Metabonomic analysis of toxic action of long-term low-level exposure to acrylamide in rat serum. Human & experimental toxicology. 2018 Dec;37(12):1282-1292. [Content Brief]
- [3]. Oto J, et al. Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study. Journal of proteomics. 2020 Apr 30;218:103723.
