2642217-95-4
Chemical Structure
HIV-1 inhibitor-29
- CAS No.: 2642217-95-4
- Formula:C30H36N6O5
- Molecular Weight:560.64
IUPAC Name: 4-((6,7-dimethoxy-2-((1-(2-morpholino-2-oxoethyl)piperidin-4-yl)amino)quinazolin-4-yl)oxy)-3,5-dimethylbenzonitrile
InChIKey: GGMBYLKLQQWUTO-UHFFFAOYSA-N
SMILES: COC1=CC2=NC(NC3CCN(CC3)CC(N4CCOCC4)=O)=NC(OC5=C(C=C(C=C5C)C#N)C)=C2C=C1OC
Biological Activity: HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS[1].
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HIV-1 inhibitor-29 | HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS. | |||||||||||||||||||||
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Keywords
