2654791-96-3
Chemical Structure
GPR84 antagonist 9
- CAS No.: 2654791-96-3
- Formula:C25H26F3N5O4
- Molecular Weight:517.50
InChIKey: DJDQNPKTGQGCPY-CJNGLKHVSA-N
SMILES: FC(F)(F)C1=C(C(NCC2=NC=C(C3CC3)N=C2)=O)OC4=C1C5=NN(C[C@@H]6OCCOC6)C=C5[C@H](C)C4
Biological Activity: GPR84 antagonist 9 is an orally active GPR84 antagonist with an IC50 value of 12 nM. By antagonizing the GPR84 receptor, GPR84 antagonist 9 blocks immune cell migration, M1 polarization, and the release of inflammatory factors (IL1β/TNFα) induced by medium-chain free fatty acids (MCFFAs) and other substances, thereby comprehensively inhibiting inflammatory and fibrotic responses. GPR84 antagonist 9 can be used in the research of inflammation-driven pain disorders, including neuropathic pain disorders, Fabry disease, gout, and bladder pain syndrome[1].
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GPR84 antagonist 9 | GPR84 antagonist 9 is an orally active GPR84 antagonist with an IC50 value of 12 nM. By antagonizing the GPR84 receptor, GPR84 antagonist 9 blocks immune cell migration, M1 polarization, and the release of inflammatory factors (IL1β/TNFα) induced by medium-chain free fatty acids (MCFFAs) and other substances, thereby comprehensively inhibiting inflammatory and fibrotic responses. GPR84 antagonist 9 can be used in the research of inflammation-driven pain disorders, including neuropathic pain disorders, Fabry disease, gout, and bladder pain syndrome. | |||||||||||||||||||||
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