2673232-30-7
Chemical Structure
CHNQD-01426
- CAS No.: 2673232-30-7
- Formula:C18H16N2O5
- Molecular Weight:340.33
IUPAC Name: 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one
InChIKey: WKVIALFFWANUDX-UHFFFAOYSA-N
SMILES: O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
Biological Activity: CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model[1][2].
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CHNQD-01426 | CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model. | |||||||||||||||||||||
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References
- [1]. Wang CJ, et al. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. Eur J Med Chem. 2021 Nov 15;224:113671. [Content Brief]
- [2]. Zhang Q, et al. Recent advances of bioactive marine natural products in drug discovery[J]. Journal of Ocean University of China, 2024, 23(5): 1297-1318.
