2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Epigenetics Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. Apoptosis Reactive Oxygen Species (ROS) PARP Caspase Akt
  4. CHNQD-01426

CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model.

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CHNQD-01426

CHNQD-01426 Chemical Structure

CAS No. : 2673232-30-7

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CHNQD-01426 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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Akt Akt1 Akt2 Akt3

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Description

CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model[1][2].

IC50 & Target[1]

Caspase 3

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
3.88 μM
Compound: 4a
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
Bel-7402 IC50
1.71 μM
Compound: 4a
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
HCT-116 IC50
5.47 μM
Compound: 4a
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
HepG2 IC50
1.22 μM
Compound: 4a
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
L02 IC50
6.01 μM
Compound: 4a
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
NCI-H1299 IC50
13.94 μM
Compound: 4a
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
U-251 IC50
5.48 μM
Compound: 4a
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
Molecular Weight

340.33

Formula

C18H16N2O5
CAS No.
SMILES

O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CHNQD-01426 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-014262673232-30-7CHNQD01426CHNQD 01426ApoptosisReactive Oxygen Species (ROS)PARPCaspaseAktpoly ADP ribose polymerase PKBProtein kinase BAnticancerCytotoxicHepG2 cellsBel-7402 cellsA549 cellsU251 cellsHepG2 xenograft mice modelInhibitorinhibitorinhibit

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