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Cat. No.: HY-177268

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CHNQD-01426

CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model.

For research use only. We do not sell to patients.

CAS No.: 2673232-30-7
Formula: C₁₈H₁₆N₂O₅
Molecular Weight:340.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CHNQD-01426 Chemical Structure

CAS No.: 2673232-30-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Caspase 3

All PARP Isoforms :

All Caspase Isoforms :

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	3.88 μM Compound: 4a	Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
Bel-7402	IC₅₀	1.71 μM Compound: 4a	Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
HCT-116	IC₅₀	5.47 μM Compound: 4a	Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
HepG2	IC₅₀	1.22 μM Compound: 4a	Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
L02	IC₅₀	6.01 μM Compound: 4a	Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
NCI-H1299	IC₅₀	13.94 μM Compound: 4a	Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]
U-251	IC₅₀	5.48 μM Compound: 4a	Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay	[PMID: 34237623]

Chemical Information

CAS No. 2673232-30-7
Molecular Weight 340.33
Formula C₁₈H₁₆N₂O₅
SMILES

O=C1NC(C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=NC3=CC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang CJ, et al. Discovery of penipanoid C-inspired 2-(3,4,5-trimethoxybenzoyl)quinazolin-4(3H)-one derivatives as potential anticancer agents by inhibiting cell proliferation and inducing apoptosis in hepatocellular carcinoma cells. Eur J Med Chem. 2021 Nov 15;224:113671. [Content Brief]

[2]. Zhang Q, et al. Recent advances of bioactive marine natural products in drug discovery[J]. Journal of Ocean University of China, 2024, 23(5): 1297-1318.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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CHNQD-01426

All PARP Isoforms

All Caspase Isoforms

All Akt Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CHNQD-01426 Related Classifications

HY-177268 Related Classifications