2673400-91-2
2673400-91-2
Chemical Structure
SHP2-IN-14
- CAS No.: 2673400-91-2
- Formula:C22H20Cl2N8O
- Molecular Weight:483.35
InChIKey: KVYQUJXENRXDEN-UHFFFAOYSA-N
SMILES: O=C(C1=C2C(C3=C(Cl)C(Cl)=NC=C3)=NNC2=NC(N4CCC(C5=CC=CC=C5)(N)CC4)=N1)N
Biological Activity: SHP2-IN-14 (compound 27) is an orally active and potent SHP2 allosteric inhibitor (IC50=7 nM) with anti-tumor activity. SHP2-IN-14 inhibits tumor progression in NCI-H358 tumor bearing mice, exhibits good pharmacokinetic characteristics and safty[1].
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SHP2-IN-14 | SHP2-IN-14 (compound 27) is an orally active and potent SHP2 allosteric inhibitor (IC50=7 nM) with anti-tumor activity. SHP2-IN-14 inhibits tumor progression in NCI-H358 tumor bearing mice, exhibits good pharmacokinetic characteristics and safty. | |||||||||||||||||||||
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References
Keywords
