2747915-75-7
Chemical Structure
Simvastatin acid-d6
Synonym(s): Tenivastatin-d6
- CAS No.: 2747915-75-7
- Formula:C25H34D6O6
- Molecular Weight:442.62
InChIKey: XWLXKKNPFMNSFA-QDGXURMLSA-N
SMILES: O=C(O)C[C@H](O)C[C@H](O)CC[C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@H](OC(C(CC)(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@]12[H]
Biological Activity: Simvastatin acid-d6 (Tenivastatin-d6) is deuterium labeled Simvastatin acid. Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1][2].
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Simvastatin acid-d6 | Simvastatin acid-d6 (Tenivastatin-d6) is deuterium labeled Simvastatin acid. Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | |||||||||||||||||||||
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Simvastatin acid | 98.99% | Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene. | ||||||||||||||||||||
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Similarity Score 0.93
HY-119695ARSimvastatin acid ammonium (Standard) -
Similarity Score 0.91
HY-W701456Simvastatin impurity 8 -
Similarity Score 0.91
HY-115292Simvastatin hydroxy acid sodium -
Similarity Score 0.89
HY-W703362Simvastatin impurity 13 -
Similarity Score 0.87
HY-122439Lovastatin acid -
Similarity Score 0.83
HY-Z15861Simvastatin impurity 7 -
Similarity Score 0.82
HY-W699488Simvastatin impurity 2 sodium -
Similarity Score 0.81
HY-123672S(rel)-Lovastatin hydroxy acid-d3 sodium -
Similarity Score 0.80
HY-123672Lovastatin hydroxy acid sodium -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Eduardo Filipe Oliveira, et al. HMG-CoA Reductase inhibitors: an updated review of patents of novel compounds and formulations (2011-2015). Expert Opin Ther Pat. 2016 Nov;26(11):1257-1272. [Content Brief]
