2750895-97-5
2750895-97-5
Chemical Structure
MTX115325
- CAS No.: 2750895-97-5
- Formula:C18H16N6O2
- Molecular Weight:348.36
InChIKey: LBHXWJUYDOSAAH-DFBGVHRSSA-N
SMILES: O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C
Biological Activity: MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine[1].
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MTX115325 | 99.91% | MTX115325 (Example 1) is an orally active, brain-penetrating USP30 inhibitor (IC50=12 nM) with neuroprotective activity. MTX115325 increases ubiquitination (EC50=32 nM) of the mitochondrial outer membrane protein TOM20 (a USP30 substrate), increasing mitophagy. MTX115325 prevents dopaminergic neuron loss and preserves striatal dopamine. | ||||||||||||||||||||
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References
Keywords
