2763577-75-7
2763577-75-7
Chemical Structure
FTO-IN-5
- CAS No.: 2763577-75-7
- Formula:C23H18Cl2N6O6
- Molecular Weight:545.33
IUPAC Name: (E)-4-(2-(4-((3,5-dichloro-2-methyl-4-((2-nitrophenyl)amino)phenyl)amino)nicotinoyl)hydrazinyl)-4-oxobut-2-enoic acid
InChIKey: LIJIAAXHNOJKMP-VOTSOKGWSA-N
SMILES: OC(/C=C/C(NNC(C1=CN=CC=C1NC(C=C2Cl)=C(C)C(Cl)=C2NC3=CC=CC=C3[N+]([O-])=O)=O)=O)=O
Biological Activity: FTO-IN-5 is a potent and selective FTO inhibitor, with an IC50 of 0.087 μM for FTO demethylase activity and a Kd of 28.0 nM for direct binding to FTO. The IC50 of FTO-IN-5 for ALKBH5 is 8.98 μM. FTO-IN-5 can be used in studies related to FTO demethylase activity and cancer[1].
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FTO-IN-5 | FTO-IN-5 is a potent and selective FTO inhibitor, with an IC50 of 0.087 μM for FTO demethylase activity and a Kd of 28.0 nM for direct binding to FTO. The IC50 of FTO-IN-5 for ALKBH5 is 8.98 μM. FTO-IN-5 can be used in studies related to FTO demethylase activity and cancer. | |||||||||||||||||||||
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