2765254-39-3
2765254-39-3
Chemical Structure
KRAS G12D inhibitor 14
- CAS No.: 2765254-39-3
- Formula:C20H19F3N4OS
- Molecular Weight:420.45
IUPAC Name: 4-(2,5-diazabicyclo[2.2.2]octan-2-yl)-6-(2-methoxy-5-(trifluoromethyl)phenyl)thieno[2,3-d]pyrimidine
InChIKey: DYYANULKLUNJSO-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1C2=CC3=C(N=CN=C3S2)N4CC5CCC4CN5)C(F)(F)F
Biological Activity: KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D[1].
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KRAS G12D inhibitor 14 | 98.88% | KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a KD of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D. | ||||||||||||||||||||
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