2790425-52-2
Chemical Structure
TNI-97
- CAS No.: 2790425-52-2
- Formula:C19H15F3N6O2
- Molecular Weight:416.36
IUPAC Name: N-hydroxy-4-((3-(1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-5-(trifluoromethyl)-1H-pyrazol-1-yl)methyl)benzamide
InChIKey: UOVFUVPAQUCHSN-UHFFFAOYSA-N
SMILES: CN1N=NC2=C1C=CC(C3=NN(CC4=CC=C(C=C4)C(NO)=O)C(C(F)(F)F)=C3)=C2
Biological Activity: TNI-97 is a selective and orally active HDAC6 inhibitor, with an IC50 of 0.2 nM. TNI-97 potently inhibited TNBC cell MDA-MB-453 growth and clonogenicity. TNI-97 induces PANoptosis including apoptosis, necroptosis and pyroptosis in MDA-MB-453 cells. TNI-97 shows antitumor activity in the mice carrying the MDA-MB-453 xenograft or carrying murine-derived TNBC cell allografts. TNI-97 can be used for the study of triple-negative breast cancer[1].
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TNI-97 | TNI-97 is a selective and orally active HDAC6 inhibitor, with an IC50 of 0.2 nM. TNI-97 potently inhibited TNBC cell MDA-MB-453 growth and clonogenicity. TNI-97 induces PANoptosis including apoptosis, necroptosis and pyroptosis in MDA-MB-453 cells. TNI-97 shows antitumor activity in the mice carrying the MDA-MB-453 xenograft or carrying murine-derived TNBC cell allografts. TNI-97 can be used for the study of triple-negative breast cancer. | |||||||||||||||||||||
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Keywords
