2806031-94-5
2806031-94-5
Chemical Structure
NIC-0102
- CAS. Nr.: 2806031-94-5
- Formula:C21H25BF2N2O4
- Molecular Weight:418.24
IUPAC Name: ((R)-1-((S)-2-(2,6-difluorobenzamido)-3-phenylpropanamido)-3-methylbutyl)boronic acid
InChIKey: QTRFWSIBLJYXFJ-ROUUACIJSA-N
SMILES: CC(C[C@@H](B(O)O)NC([C@@H](NC(C1=C(C=CC=C1F)F)=O)CC2=CC=CC=C2)=O)C
Biological Activity: NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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NIC-0102 | 98.79% | NIC-0102 is an orally active proteasome inhibitor (pIC50=7.55) that specifically inhibits NLRP3 inflammatory vesicle activation. NIC-0102 shows potent anti-inflammatory effects in a model of dextran sulfate sodium (DSS)-induced ulcerative colitis. NIC-0102 also inhibits production of pro-IL-1β. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-10227Bortezomib -
Similarity Score 0.71
HY-135396(1S,2S)-Bortezomib -
Similarity Score 0.62
HY-156052CN-716 dihydrochloride -
Similarity Score 0.56
HY-P4844Ac-Phe-Phe-OH -
Similarity Score 0.56
HY-N2909Aurantiamide -
Similarity Score 0.56
HY-P3556Benzoyl-Phe-Ala-Arg -
Similarity Score 0.55
HY-100522FMK 9a -
Similarity Score 0.55
HY-116472alpha-RA-F -
Similarity Score 0.55
HY-114939Phelorphan -
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