2849471-75-4
2849471-75-4
Chemical Structure
WLB-89462
- CAS. Nr.: 2849471-75-4
- Formula:C21H29N5O3
- Molecular Weight:399.49
InChIKey: HPBOMWKBZHYYGE-UHFFFAOYSA-N
SMILES: O=C(CN1CCC(CC1)C2=C(C3=CC(C)=NO3)C=NC(CC)=N2)N4CCOCC4
Biological Activity: WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents)[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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WLB-89462 | 98.70% | WLB-89462 (Compound 20c) is a selective σ2 receptor ligand (Ki: 13 nM). WLB-89462 has neuroprotective activity. WLB-89462 improves short-term memory impairment induced by Aβ peptide in rats. WLB-89462 has good ADMET profile (good solubility, no CYP inhibition, good metabolic stability, high permeability, brain penetration, and high oral exposure in rodents). | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.47
HY-139980CDK9-IN-13 -
Similarity Score 0.44
HY-153133CFTR corrector 11 -
Similarity Score 0.43
HY-103424A-412997 dihydrochloride -
Similarity Score 0.43
HY-101349AL 741742 hydrochloride -
Similarity Score 0.43
HY-11087SD 0006 -
Similarity Score 0.43
HY-U00324p38 MAPK-IN-2 -
Similarity Score 0.43
HY-101349L 741742 -
Similarity Score 0.42
HY-129103A-412997 -
Similarity Score 0.42
HY-176488Y-99 -
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