2865185-31-3
Chemical Structure
25N-N1-Nap
- CAS No.: 2865185-31-3
- Formula:C21H22N2O4
- Molecular Weight:366.41
InChIKey: ALVHBRTUOXXMDK-UHFFFAOYSA-N
SMILES: COC1=CC(CCNCC2=C3C=CC=CC3=CC=C2)=C(C=C1[N+]([O-])=O)OC
Biological Activity: 25N-N1-Nap is a blood-brain barrier-permeable, selective, β-arrestin2-biased 5-HT2A receptor (5-HT2AR) agonist. 25N-N1-Nap reduces Gq efficacy while preserving β-arrestin2 efficacy. 25N-N1-Nap does not induce hallucinogen-like behavioral responses, blocks hyperactivity induced by hallucinogens and psychostimulants, and induces rapid tolerance to hallucinogen-like responses. 25N-N1-Nap can be used for research on schizophrenia-related hyperactivity[1][2].
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25N-N1-Nap | 25N-N1-Nap is a blood-brain barrier-permeable, selective, β-arrestin2-biased 5-HT2A receptor (5-HT2AR) agonist. 25N-N1-Nap reduces Gq efficacy while preserving β-arrestin2 efficacy. 25N-N1-Nap does not induce hallucinogen-like behavioral responses, blocks hyperactivity induced by hallucinogens and psychostimulants, and induces rapid tolerance to hallucinogen-like responses. 25N-N1-Nap can be used for research on schizophrenia-related hyperactivity. | |||||||||||||||||||||
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- [1]. Wallach J, et al. Identification of 5-HT receptor signaling pathways associated with psychedelic potential. Nature communications. 2023 Dec 15;14(1):8221. [Content Brief]
- [2]. Fannana T. Design, Syntheses and Structure Activity Relationship Characterizations of 5-HT2A Receptor Ligands[D]. Saint Joseph's University, 2025.
Keywords
