25N-N1-Nap
25N-N1-Nap is a blood-brain barrier-permeable, selective, β-arrestin2-biased 5-HT2A receptor (5-HT2AR) agonist. 25N-N1-Nap reduces Gq efficacy while preserving β-arrestin2 efficacy. 25N-N1-Nap does not induce hallucinogen-like behavioral responses, blocks hyperactivity induced by hallucinogens and psychostimulants, and induces rapid tolerance to hallucinogen-like responses. 25N-N1-Nap can be used for research on schizophrenia-related hyperactivity.
For research use only. We do not sell to patients.
- CAS No.: 2865185-31-3
- Formula: C21H22N2O4
- Molecular Weight:366.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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5-HT2A Receptor |
25N-N1-Nap is a β-arrestin-biased agonist of the 5-HT2A receptor, with reduced efficacy in the Gq pathway but preserved efficacy in the β-arrestin2 pathway, and it exhibits selectivity for the 5-HT2A receptor over the 5-HT2B and 5-HT2C receptors[1].
25N-N1-Nap (0.001 nM-0.1 mM; 60 min) induces significant internalization of the 5-HT2A receptor in the presence of co-expressed β-arrestin2, which is consistent with its β-arrestin-biased agonist profile[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
25N-N1-Nap (20 mg/kg; s.c.; once daily; 5 days) induces tachyphylaxis to the HTR induced by (±)-DOI in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 J (male)[1]
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Dosage:20 mg/kg
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Administration:s.c.; once daily; 5 days
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Result:Reduced the ability of a challenge dose of (±)-DOI to induce the head-twitch response (HTR), indicating induction of tachyphylaxis.
Chemical Information
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CAS No. 2865185-31-3
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Molecular Weight 366.41
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Formula C21H22N2O4
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SMILES
COC1=CC(CCNCC2=C3C=CC=CC3=CC=C2)=C(C=C1[N+]([O-])=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
25N-N1-Nap Related Classifications
HY-157429 Related Classifications
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