2884554-45-2
Chemical Structure
UBX-382
- CAS No.: 2884554-45-2
- Formula:C42H44N10O4
- Molecular Weight:752.86
InChIKey: WIAKHDZSMZDZQL-UHFFFAOYSA-N
SMILES: O=C1C2=CC=C(N3CCC(CC3)CN4CC5=CC(NC6=NC7=C(C(NC8=C(C)C=CC=C8C)=NN7C)C=N6)=CC=C5CC4)C=C2C(N1C9C(NC(CC9)=O)=O)=O
Biological Activity: UBX-382 is an orally active BTK PROTAC degrader with a DC50 of 4.56 nM. UBX-382 inhibits B-cell receptor signaling by targeting BTK. UBX-382 shows superior degradation activity for wild-type and mutant BTK proteins. UBX-382 inhibits tumor growth in murine xenograft models harboring wild-type or C481S mutant BTK-expressing TMD-8 cells. UBX-382 can be used for the study of B-cell-related blood cancers[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
UBX-382 | 96.20% | UBX-382 is an orally active BTK PROTAC degrader with a DC50 of 4.56 nM. UBX-382 inhibits B-cell receptor signaling by targeting BTK. UBX-382 shows superior degradation activity for wild-type and mutant BTK proteins. UBX-382 inhibits tumor growth in murine xenograft models harboring wild-type or C481S mutant BTK-expressing TMD-8 cells. UBX-382 can be used for the study of B-cell-related blood cancers. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.62
HY-161708PROTAC FLT3/CDKs degrader-1 -
Similarity Score 0.61
HY-149324SP27 -
Similarity Score 0.59
HY-158313PROTAC EGFR degrader 13 -
Similarity Score 0.59
HY-153386CPD-1224 -
Similarity Score 0.59
HY-159610GSPT1 degrader-10 -
Similarity Score 0.58
HY-153220Zelebrudomide -
Similarity Score 0.58
HY-153220A(R)-Zelebrudomide -
Similarity Score 0.57
HY-145073PROTAC ER Degrader-10 -
Similarity Score 0.57
HY-181050DFCI-002-06 -
Explore the MedChemAI to find more analogs
