2890191-41-8
2890191-41-8
Chemical Structure
AZD4144
- CAS No.: 2890191-41-8
- Formula:C18H16F3N3O3
- Molecular Weight:379.33
InChIKey: CEGVLCNHZDUFIJ-NSHDSACASA-N
SMILES: OC1=C(C2=C(C=CC=C3)C3=C(NC[C@H](O)CO)N=N2)C=CC(C(F)(F)F)=C1
Biological Activity: AZD4144 is an orally active NLRP3 inhibitor (EC50: 0.082 μM). AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD4144 | 99.33% | AZD4144 is an orally active NLRP3 inhibitor (EC50: 0.082 μM). AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.68
HY-164765NLRP3-IN-56 -
Similarity Score 0.59
HY-163497NLRP3-IN-38 -
Similarity Score 0.59
HY-148187NLRP3-IN-11 -
Similarity Score 0.55
HY-153554NLRP3-IN-18 -
Similarity Score 0.54
HY-182102NLRP3-IN-88 -
Similarity Score 0.53
HY-177128Sebrinoflast -
Similarity Score 0.52
HY-163179NLRP3-IN-28 -
Similarity Score 0.52
HY-19184MKC-963 -
Similarity Score 0.51
HY-163498NLRP3-IN-37 -
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