2890191-41-8
2890191-41-8
Chemical Structure
AZD4144
- CAS No.: 2890191-41-8
- Formula:C18H16F3N3O3
- Molecular Weight:379.33
InChIKey: CEGVLCNHZDUFIJ-NSHDSACASA-N
SMILES: OC1=C(C2=C(C=CC=C3)C3=C(NC[C@H](O)CO)N=N2)C=CC(C(F)(F)F)=C1
Biological Activity: AZD4144 is an orally active NLRP3 inhibitor (EC50: 0.082 μM). AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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AZD4144 | 99.67% | AZD4144 is an orally active NLRP3 inhibitor (EC50: 0.082 μM). AZD4144 effectively inhibits the release of IL-1β when NLRP3 is overactivated, exerting an anti-inflammatory effect. AZD4144 has low inhibitory effect on hERG and low cardiotoxicity. AZD4144 has the potential to study diseases and conditions associated with NLRP3 inflammasome activation. | ||||||||||||||||||||
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References
Keywords
