2899209-55-1
Chemical Structure
JAB-2485
- CAS No.: 2899209-55-1
- Formula:C25H28ClF2N5O2
- Molecular Weight:503.97
InChIKey: CEONSWRDFKMFNM-PUAOIOHZSA-N
SMILES: ClC1=CC=CC(CN2CC[C@](C(O)=O)(CC3=CC(C)=C(F)C(NC4=CC(C)=NN4)=N3)C[C@H]2C)=C1F
Biological Activity: JAB-2485 is an orally active and selective Aurora kinase A (AURKA) inhibitor with an IC50 value of 0.327 nM. JAB-2485 exhibits inhibitory activity against various tumor cell lines such as neuroblastoma, triple-negative breast cancer, small cell lung cancer, and epithelial ovarian cancer. JAB-2485 can induce cell cycle arrest and apoptosis in tumor cells. JAB-2485 has antitumor activity[1][2].
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JAB-2485 | 99.87% | JAB-2485 is an orally active and selective Aurora kinase A (AURKA) inhibitor with an IC50 value of 0.327 nM. JAB-2485 exhibits inhibitory activity against various tumor cell lines such as neuroblastoma, triple-negative breast cancer, small cell lung cancer, and epithelial ovarian cancer. JAB-2485 can induce cell cycle arrest and apoptosis in tumor cells. JAB-2485 has antitumor activity. | ||||||||||||||||||||
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Similarity Score 0.79
HY-143713Aurora A inhibitor 1 -
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HY-114258LY3295668 -
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HY-114258ALY3295668 erbumine -
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HY-179643Aurora-A ligand 2 -
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HY-137377TAS-119 -
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HY-13252MK-5108 -
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HY-13034Gandotinib -
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HY-1624696K465 -
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HY-174986CGRP antagonist 7 -
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References
- [1]. Yang G, et al. Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties. ACS Omega. 2024 May 3;9(19):21416-21425. [Content Brief]
- [2]. Yang G, et, al. Abstract 1645: JAB-2485: A potent, highly selective small-molecule Aurora kinase A inhibitor that targets cell division. Cancer Res (2023) 83 (7_Supplement): 1645.
