2922402-03-5
2922402-03-5
Chemical Structure
EGFR kinase inhibitor 3
- CAS No.: 2922402-03-5
- Formula:C31H25N7O3S
- Molecular Weight:575.64
InChIKey: LYRJTYBPIGJFCT-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C2=C(NC(SC)=N2)C3=CC=NC(NC(C)=O)=C3)=C1)C4=C5NC(C6=C(NC5=CC=C4)C=CC=C6)=O
Biological Activity: EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR kinase inhibitor 3 | 99.03% | EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor. | ||||||||||||||||||||
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References
Keywords
