2922402-03-5
2922402-03-5
Chemical Structure
EGFR kinase inhibitor 3
- CAS No.: 2922402-03-5
- Formula:C31H25N7O3S
- Molecular Weight:575.64
InChIKey: LYRJTYBPIGJFCT-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(C2=C(NC(SC)=N2)C3=CC=NC(NC(C)=O)=C3)=C1)C4=C5NC(C6=C(NC5=CC=C4)C=CC=C6)=O
Biological Activity: EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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EGFR kinase inhibitor 3 | 99.03% | EGFR kinase inhibitor 3 (compound 2) is a bivalent ATP-allosteric EGFR kinase inhibitor with IC50s of <10 nM, 1.5 nM, 0.059 nM, 0.064 nM for WT EGFR, EGFR-activating mutations L858R, L858R/T790M and L858R/T790M/C797S, respectively. EGFR kinase inhibitor 3 is a C-linked inhibitor. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.71
HY-139884EGFR-IN-18 -
Similarity Score 0.69
HY-162300EGFR kinase inhibitor 4 -
Similarity Score 0.52
HY-110103RML3403 (Standard) -
Similarity Score 0.51
HY-112389p38 MAP Kinase Inhibitor III -
Similarity Score 0.49
HY-12280THZ2 -
Similarity Score 0.49
HY-117991DW10075 -
Similarity Score 0.48
HY-171279Casein kinase 1δ-IN-29 -
Similarity Score 0.47
HY-80013THZ1 -
Similarity Score 0.47
HY-19988THZ1-R -
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