2956716-97-3
2956716-97-3
Chemical Structure
YF704
- CAS No.: 2956716-97-3
- Formula:C17H20Cl2N4OS2
- Molecular Weight:431.40
InChIKey: KHRPDZUCNPWUNK-IINYFYTJSA-N
SMILES: N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4
Biological Activity: YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells[1].
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YF704 | YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells. | |||||||||||||||||||||
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References
Keywords
