2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. YF704

YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells.

For research use only. We do not sell to patients.

YF704 Chemical Structure

YF704 Chemical Structure

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YF704 Related Antibodies

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Description

YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells[1].

Molecular Weight

431.40

Formula

C17H20Cl2N4OS2
SMILES

N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YF704 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YF704YF 704YF-704SHP2Src homology phosphatase 2PTPN11MV4-11NCI-H358cancerapoptosisErk1/2AktInhibitorinhibitorinhibit

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