2. Protein Tyrosine Kinase/RTK
  3. SHP2
  4. YF704

YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells.

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YF704

YF704 Chemical Structure

CAS No. : 2956716-97-3

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YF704 Related Antibodies

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Description

YF704 (compound 4w) is a selective allosteric inhibitor of SHP2 (IC50=0.25 μM). YF704 shows antiproliferative activity and induces apoptosis in cancer cells. YF704 also downregulates Erk1/2 and Akt phosphorylation levels in cancer cells[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
12.12 μM
Compound: 4w; YF704
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
[PMID: 37390510]
MDA-MB-468 IC50
14.58 μM
Compound: 4w; YF704
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
Antiproliferative activity against human MDA-MB-468 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
[PMID: 37390510]
MV4-11 IC50
3.85 μM
Compound: 4w; YF704
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
[PMID: 37390510]
NCI-H358 IC50
12.01 μM
Compound: 4w; YF704
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell growth measured after 72 hrs by CCK8 method
[PMID: 37390510]
Molecular Weight

431.40

Formula

C17H20Cl2N4OS2
CAS No.
SMILES

N[C@@H]1[C@H](C)OCC12CCN(CC2)C(S3)=NN=C3SC4=C(Cl)C(Cl)=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YF704 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YF7042956716-97-3YF 704YF-704SHP2Src homology phosphatase 2PTPN11MV4-11NCI-H358cancerapoptosisErk1/2AktInhibitorinhibitorinhibit

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