296771-07-8
296771-07-8
Chemical Structure
dCeMM2
- CAS No.: 296771-07-8
- Formula:C16H11ClN6OS
- Molecular Weight:370.82
IUPAC Name: 2-((5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide
InChIKey: VFWVTIHYVUKNGR-UHFFFAOYSA-N
SMILES: O=C(NC1=NC=C(Cl)C=C1)CSC2=NN=C3C(NC4=C3C=CC=C4)=N2
Biological Activity: dCeMM2 (Compound 2) is a molecular glue-type degrader that targets cyclin K. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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dCeMM2 | 99.25% | dCeMM2 (Compound 2) is a molecular glue-type degrader that targets cyclin K. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. | ||||||||||||||||||||
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References
- [1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling [published correction appears in Nat Chem Biol. 2021 Mar;17(3):361]. Nat Chem Biol. 2020;16(11):1199-1207. [Content Brief]
- [2]. Jochem M, et al. Degradome analysis to identify direct protein substrates of small-molecule degraders[J]. bioRxiv, 2024: 2024.01. 28.577572.
- [3]. Dong G, et al. Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. J Med Chem. 2021 Aug 12;64(15):10606-10620. [Content Brief]
Keywords
