2988762-46-3
2988762-46-3
Chemical Structure
HDAC3-IN-4
- CAS No.: 2988762-46-3
- Formula:C22H25N5O2S
- Molecular Weight:423.53
InChIKey: VPTDKGALTAWWPE-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(CNC2=CC=CC=C2)S1)NCC3=CC=C(C(NNCCC)=O)C=C3
Biological Activity: HDAC3-IN-4 is a selective and orally active HDAC3 inhibitor with an IC50 of 89 nM. HDAC3-IN-4 induces the degradation of PD-L1 by regulating cathepsin B (CTSB) in the lysosomes, with a DC50 of 5.7 μM. HDAC3-IN-4 shows better selectivity for HDAC3 over HDAC1, HDAC6, HDAC7, and HDAC8[1].
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HDAC3-IN-4 | HDAC3-IN-4 is a selective and orally active HDAC3 inhibitor with an IC50 of 89 nM. HDAC3-IN-4 induces the degradation of PD-L1 by regulating cathepsin B (CTSB) in the lysosomes, with a DC50 of 5.7 μM. HDAC3-IN-4 shows better selectivity for HDAC3 over HDAC1, HDAC6, HDAC7, and HDAC8. | |||||||||||||||||||||
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References
Keywords
