3023019-99-7
Chemical Structure
HDAC6-IN-3
- CAS No.: 3023019-99-7
- Formula:C19H27N3O3
- Molecular Weight:345.44
IUPAC Name: N1-hydroxy-N8-(3-((methyl(prop-2-yn-1-yl)amino)methyl)phenyl)octanediamide
InChIKey: FQVRLKIMFQKGHF-UHFFFAOYSA-N
SMILES: O=C(CCCCCCC(NC1=CC=CC(CN(CC#C)C)=C1)=O)NO
Biological Activity: HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC50s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective MAO-A (IC50=0.79 μM) and LSD1 inhibitor[1]. HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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HDAC6-IN-3 | 98.0% | HDAC6-IN-3 (Compound 14), an antiprostate cancer agent, is a potent, orally active HDAC6 inhibitor with IC50s ranging from 0.02-1.54 μM for HDAC1/2/3/6/8/10. HDAC6-IN-3 is also an effective MAO-A (IC50=0.79 μM) and LSD1 inhibitor. HDAC6-IN-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | ||||||||||||||||||||
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