3033608-94-2
3033608-94-2
Chemical Structure
HDAC-IN-47
- CAS No.: 3033608-94-2
- Formula:C17H20BrN3O4
- Molecular Weight:410.26
InChIKey: YNWLMVWHXKRQRH-UHFFFAOYSA-N
SMILES: O=C(C1=NC=C(C2=CC=C(Br)C=C2)O1)NCCCCCCC(NO)=O
Biological Activity: HDAC-IN-47 is an orally active inhibitor of histone deacetylase (HDAC), with IC50s of 19.75 nM (HDAC1), 5.63 nM (HDAC2), 40.27 nM (HDAC3), 57.8 nM (HDAC2), 302.73 nM (HDAC8), respectively. HDAC-IN-47 inhibits autophagy and induces apoptosis via the Bax/Bcl-2 and caspase-3 pathways. HDAC-IN-47 arrests cell cycle at G2/M phase, and shows anti-tumor efficacy in vivo[1].
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HDAC-IN-47 | HDAC-IN-47 is an orally active inhibitor of histone deacetylase (HDAC), with IC50s of 19.75 nM (HDAC1), 5.63 nM (HDAC2), 40.27 nM (HDAC3), 57.8 nM (HDAC2), 302.73 nM (HDAC8), respectively. HDAC-IN-47 inhibits autophagy and induces apoptosis via the Bax/Bcl-2 and caspase-3 pathways. HDAC-IN-47 arrests cell cycle at G2/M phase, and shows anti-tumor efficacy in vivo. | |||||||||||||||||||||
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References
Keywords
