3044-32-4
3044-32-4
Chemical Structure
Clogestone acetate
Synonym(s): AY-11440
- CAS No.: 3044-32-4
- Formula:C25H33ClO5
- Molecular Weight:448.98
IUPAC Name: (3S,8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-dimethyl-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diyl diacetate
InChIKey: KSCZWFXQKITHSL-OKCNGXCSSA-N
SMILES: CC([C@]1(CC[C@]2([C@@]3(C=C(C4=C[C@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)OC(C)=O)Cl)[H])[H])OC(C)=O)=O
Biological Activity: Clogestone acetate (AY-11440) is an orally active progesterone receptor agonist. Clogestone acetate reduces adrenal and ovarian weight, as well as serum and adrenocortical ketone levels in rats[1][2].
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Clogestone acetate | Clogestone acetate (AY-11440) is an orally active progesterone receptor agonist. Clogestone acetate reduces adrenal and ovarian weight, as well as serum and adrenocortical ketone levels in rats. | |||||||||||||||||||||
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References
- [1]. Givner ML, et al. Effect of synthetic progestogens and estradiol-17 on adrenal function in the rat. Endocrinology. 1972 May;90(5):1238-44. [Content Brief]
- [2]. Hinselmann M, et al. Klinische Untersuchungen mit dem neuartigen Gestagen Clogestonacetat [Clogestone acetate, a new orally effective progestagen]. Arch Gynakol. 1970 Aug 31;209(2):136-48. German. [Content Brief]
