304684-77-3
Chemical Structure
Exo2
- CAS No.: 304684-77-3
- Formula:C18H18N4O2S
- Molecular Weight:354.43
IUPAC Name: (E)-2-methoxy-4-((2-(5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)hydrazono)methyl)phenol
InChIKey: VFNUTEMVQGLDAG-ZVBGSRNCSA-N
SMILES: COC(C=C(C=C1)/C=N/NC2=C3C(CCCC4)=C4SC3=NC=N2)=C1O
Biological Activity: Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Exo2 | 99.57% | Exo2 is a secretion inhibitor. Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Exo2 blocks secretory cargo exit from the ER (endoplasmic reticulum) and disrupts the Golgi apparatus, but does not affect the morphology of the TGN (trans-Golgi network) Exo2 can stimulate calcium-dependent exocytosis in permeabilized adrenal chromaff in cells. | ||||||||||||||||||||
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References
- [1]. Spooner RA, et al. The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network. Biochem J. 2008 Sep 15;414(3):471-84. [Content Brief]
- [2]. Morgan A, et al. Exo1 and Exo2 proteins stimulate calcium-dependent exocytosis in permeabilized adrenal chromaffin cells. Nature. 1992 Feb 27;355(6363):833-6. [Content Brief]
