3056388-71-4

JNK-1-IN-3 Chemical Structure
3056388-71-4

Chemical Structure

JNK-1-IN-3

  • CAS No.: 3056388-71-4
  • Formula:C19H17FN4O3
  • Molecular Weight:368.36

InChIKey: IVQFVONPJQHLCE-UHFFFAOYSA-N

SMILES: O=C(NNC1=NN=C(C2=CC=C(OC)C(OC)=C2)C=C1)C3=CC=C(F)C=C3

Biological Activity: JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity[1].

Cat. No. Product Name Purity Description Pricing
HY-169021 		JNK-1-IN-3 98.44% JNK-1-IN-3 (Compound 9e) is an inhibitor of JNK1 that downregulates JNK1 gene expression and inhibits the protein levels of its phosphorylated form, concurrently reducing the expression of its downstream targets, c-Jun and c-Fos, in tumors while restoring p53 activity. JNK-1-IN-3 exhibits broad-spectrum antiproliferative activity, particularly with high inhibitory activity against renal and breast cancer cell lines, demonstrating both in vivo and in vitro anticancer activity.
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This compound is listed in the SVHC (Substances of Very High Concern) candidate list of ECHA (European Chemicals Agency).

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Structural Analogs

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