3057263-82-5
3057263-82-5
Chemical Structure
CK1δ-IN-9
- CAS. Nr.: 3057263-82-5
- Formula:C16H12FN5
- Molecular Weight:293.30
SMILES: FC1=CC=C(C2=NN(C)C=C2C3=C4C=NNC4=NC=C3)C=C1
Biological Activity: CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance[1].
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CK1δ-IN-9 | CK1δ-IN-9 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1δ with IC50 of 1.4 nM. CK1δ-IN-9 inhibits p38α and p38β with IC50 of 0.25 μM and 0.78 μM. CK1δ-IN-9 exhibits pharmacokinetic characteristics with a good oral bioavailability (70%) and a moderate clearance. | |||||||||||||||||||||
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