307552-53-0
Chemical Structure
SLC26A3-IN-1
- CAS No.: 307552-53-0
- Formula:C23H18O4
- Molecular Weight:358.39
IUPAC Name: 5-((2-methylbenzyl)oxy)-2-phenylbenzofuran-3-carboxylic acid
InChIKey: YWWXFTRVVNQMNQ-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC=C2)OC3=C1C=C(OCC4=C(C)C=CC=C4)C=C3)O
Biological Activity: SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
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SLC26A3-IN-1 | SLC26A3-IN-1 is an inhibitor of anion exchanger protein SLC26A3 (IC50=340 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea. | |||||||||||||||||||||
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