3078752-74-3
Chemical Structure
CSMPP
- CAS No.: 3078752-74-3
- Formula:C25H24N4
- Molecular Weight:380.48
InChIKey: XUVMGDXYGILIKD-HKOYGPOVSA-N
SMILES: N#C/C(C1=CC=C(C2=CC=NC=C2)C=C1)=C\C3=CC=C(N4CCN(C)CC4)C=C3
Biological Activity: CSMPP is a ratiometric lysosomal pH fluorescent probe with aggregation-induced emission (AIE) properties, which is used for real-time quantitative detection of lysosomal pH changes in living cells and in vivo. CSMPP has a cyanodistyrene backbone, and contains N-methylpiperazine and pyridine groups (pH-responsive); protonation of the pyridine group significantly enhances intramolecular charge transfer (ICT), leading to green fluorescence emission (Ex/Em = 405/503 nm) under neutral/basic conditions and red fluorescence emission (Ex/Em = 405/615 nm) under acidic conditions. CSMPP exhibits high selectivity, reversibility, good biocompatibility and excellent photostability[1][2][3].
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CSMPP | CSMPP is a ratiometric lysosomal pH fluorescent probe with aggregation-induced emission (AIE) properties, which is used for real-time quantitative detection of lysosomal pH changes in living cells and in vivo. CSMPP has a cyanodistyrene backbone, and contains N-methylpiperazine and pyridine groups (pH-responsive); protonation of the pyridine group significantly enhances intramolecular charge transfer (ICT), leading to green fluorescence emission (Ex/Em = 405/503 nm) under neutral/basic conditions and red fluorescence emission (Ex/Em = 405/615 nm) under acidic conditions. CSMPP exhibits high selectivity, reversibility, good biocompatibility and excellent photostability. | |||||||||||||||||||||
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References
- [1]. Shi X, et al. In vivo monitoring of tissue regeneration using a ratiometric lysosomal AIE probe. Chem Sci. 2020;11(12):3152-3163.
- [2]. Luo Y, et al. Immune responses of oyster hemocyte subpopulations to in vitro and in vivo zinc exposure. Aquatic toxicology (Amsterdam, Netherlands). 2022 Jan;242:106022. [Content Brief]
- [3]. Yuan L, et al. Real-time in vitro monitoring of the subcellular toxicity of inorganic Hg and methylmercury in zebrafish cells. Aquatic toxicology (Amsterdam, Netherlands). 2021 Jul;236:105859.
