3079468-41-7
Chemical Structure
JNU-0921
- CAS No.: 3079468-41-7
- Formula:C19H12N2O3
- Molecular Weight:316.31
InChIKey: HLHUIWNJFGIBMS-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(C2=NOC(C3=CC(C=CC=C4)=C4C=C3)=N2)=CC=C1
Biological Activity: JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity[1].
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JNU-0921 | 99.77% | JNU-0921 is a potent and orally active CD137 agonist. JNU-0921 increases the mRNA expression of IFN-γ and GZMB. JNU-0921 induces luciferase activity with an EC50 value of 64.07 nM.JNU-0921 enhances effector and memory function of cytotoxic CD8+ T cells (CTLs) and alleviates their exhaustion. JNU-0921 also skews polarization of helper T cells toward T helper 1 type and enhances their activity to boost CTL function. JNU-0921 shows anticancer activity. | ||||||||||||||||||||
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