3090769-17-5
3090769-17-5
Chemical Structure
APP degrader-1
- CAS No.: 3090769-17-5
- Formula:C20H20N4O4S
- Molecular Weight:412.46
InChIKey: BXRIBKQPFVAZKX-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2C(SC(NC(NC3=CC(OC)=CC=C3)=O)=N2)=C1)N4CCOCC4
Biological Activity: APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein (APP) degrader that induces APP degradation and reduces the extracellular release of Aβ42. APP degrader-1 can bind to both CAPRIN1 and APP, and enhances their interaction as well as CAPRIN1-mediated APP degradation through the endosome-lysosome pathway[1].
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APP degrader-1 | 99.11% | APP degrader-1 (Compound 0152) is an orally active amyloid precursor protein (APP) degrader that induces APP degradation and reduces the extracellular release of Aβ42. APP degrader-1 can bind to both CAPRIN1 and APP, and enhances their interaction as well as CAPRIN1-mediated APP degradation through the endosome-lysosome pathway. | ||||||||||||||||||||
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References
Keywords
