3095435-97-2
Chemical Structure
MST3-IN-1
- CAS No.: 3095435-97-2
- Formula:C25H21F4N5O3S
- Molecular Weight:547.52
IUPAC Name: 1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-N-(6-(trifluoromethoxy)benzo[d]thiazol-2-yl)-1,4-dihydroquinoline-3-carboxamide
InChIKey: NQSPVWSGYLSLAQ-UHFFFAOYSA-N
SMILES: O=C(C1=CN(C2CC2)C3=CC(N4CCNCC4)=C(C=C3C1=O)F)NC5=NC6=C(S5)C=C(OC(F)(F)F)C=C6
Biological Activity: MST3-IN-1 is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 shows antiproliferative activity against HepG2 cell. MST3-IN-1 effectively induces apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 can be used for the study of liver cancer[1].
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MST3-IN-1 | MST3-IN-1 is a selective and orally active MST3 inhibitor, with an IC50 of 122.4 nM. MST3-IN-1 shows antiproliferative activity against HepG2 cell. MST3-IN-1 effectively induces apoptosis in HepG2 cells, and halts the cell cycle at the G2/M transition. MST3-IN-1 significantly suppressed tumor growth in HepG2 xenograft mice. MST3-IN-1 can be used for the study of liver cancer. | |||||||||||||||||||||
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Keywords
